The influence of different sources of polyphenols on submaximal cycling and time trial performance

The primary purpose of the study was to establish the effects of commercially available polyphenol-rich antioxidant supplements, Pycnogenol® with added bioflavonoids (PYC-B) and CherryActive (CHA), on 20 km cycling performance. Using a double-blind counterbalanced, repeated-measures design, nine male cyclists or triathletes (32.1 ± 11.2 years; maximal aerobic capacity 4.2 ± 0.7 L•min-1; maximal power output 391.7 ± 39.5 watts) consumed 200 mg of CHA, 120 mg of PYC-B, or 200 mg of placebo (PLA) capsules, 2 days before and on the day of each experimental trial. The experimental trials consisted of four 5 minute stages at 40%, 50%, 60%, and 70% maximal power output (Wmax), followed by a 20 km time trial (TT). Statistical analysis revealed no significant differences between trials for heart rate, respiratory exchange ratio, gross mechanical efficiency, oxygen consumption, or blood lactate, at any of the intensities completed during the initial 20 minute phase of the trial (p>0.05). Final 20 km TT times were not significantly different between trials (p=0.115), but, compared to PLA, PYC-B did significantly increase power output by 6.2% over the final 5 km of the TT (p=0.022). The study suggests that the PYC-B supplement could be beneficial towards the end of an intense bout of cycling exercise. However, as total 20 km time was not significantly different between trials the doses used are unlikely to benefit 20 km cycling time trial performance

Future wireless applications for a networked city: services for visitors and residents

Future wireless networks will offer near-ubiquitous high-bandwidth communications to mobile users. In addition, the accurate position of users will be known, either through network services or via additional sensing devices such as GPS. These characteristics of future mobile environments will enable the development of location-aware and, more generally, context-sensitive applications. In an attempt to explore the system, application, and user issues associated with the development and deployment of such applications, we began to develop the Lancaster GUIDE system in early 1997, finishing the first phase of the project in 1999. In its entirety, GUIDE comprises a citywide wireless network based on 802.11, a context-sensitive tour guide application with, crucially, significant content, and a set of supporting distributed systems services. Uniquely in the field, GUIDE has been evaluated using members of the general public, and we have gained significant experience in the design of usable context-sensitive applications. We focus on the applications and supporting infrastructure that will form part of GUIDE II, the successor to the GUIDE system. These developments are designed to expand GUIDE outside the tour guide domain, and to provide applications and services for residents of the city of Lancaster, offering a vision of the future mobile environments that will emerge once ubiquitous high-bandwidth coverage is available in most cities

Mobile-awareness:designing for mobile interactive systems

In recent years, we have witnessed a significant increase in the availability and adoption of mobile devices with wireless communications capabilities. Such devices can be used as the end-system in network-based (single or multi

Towards AMR Simulations of Galaxy Formation

Numerical simulations present a fundamental building block of our modern theoretical understanding of the Universe. As such the work in this thesis is primarily concerned with understanding fundamental differences that lie between the different hydrodynamic schemes. In chapter 3 I outline the optimisations I make to the FLASH code to enable larger simulations to be run. These include developing and testing a new FFT gravity solver. With these complete, in chapter 4 I present results from a collaborative code comparison project in which we test a series of different hydrodynamics codes against a suite of demanding test problems with astrophysical relevance. As the problems have known solutions, we can quantify their performance and are able to develop a resolution criteria which allows for the two different types to be reliably compared. In chapter 5 we develop an analytic model for ram pressure stripping of the hot gaseous haloes of galaxies in groups and clusters. We test the model against a suite of hydrodynamic simulations in the SPH GADGET-2 code. To ensure that the spurious suppression of hydrodynamic instabilities by SPH codes does not bias our results, I compare our findings to those obtained with the FLASH AMR code and find excellent agreement. Chapter 6 presents work in which we unambiguously determine the origin of the difference between the entropy cores formed in AMR and SPH codes. By running mergers of model clusters we are able to systematically explore the various proposed mechanisms and determine that turbulent mixing generates the higher entropy cores within AMR codes but is suppressed in SPH codes. The startling differences between the two hydrodynamic schemes presented in chapter 6 leads me to investigate their affect upon different sub-grid physical recipes. In chapter 7 I present the implementation of a sub-grid star formation recipe in FLASH and find strong differences in the way the two codes model pressure laws. I extend the work in chapter 8 by implementing a kinetic supernova feedback mechanism in FLASH and contrasting it with the results from the GADGET-2 code. I find that AMR codes dissipate energy much more efficiently than in SPH codes

Conductance fingerprint of Majorana fermions in the topological Kondo effect

We consider an interacting nanowire/superconductor heterostructure attached to metallic leads. The device is described by an unusual low-energy model involving spin-1 conduction electrons coupled to a nonlocal spin-1/2 Kondo impurity built from Majorana fermions. The topological origin of the resulting Kondo effect is manifest in distinctive non-Fermi-liquid (NFL) behavior, and the existence of Majorana fermions in the device is demonstrated unambiguously by distinctive conductance lineshapes. We study the physics of the model in detail, using the numerical renormalization group, perturbative scaling and abelian bosonization. In particular, we calculate the full scaling curves for the differential conductance in AC and DC fields, onto which experimental data should collapse. Scattering t-matrices and thermodynamic quantities are also calculated, recovering asymptotes from conformal field theory. We show that the NFL physics is robust to asymmetric Majorana-lead couplings, and here we uncover a duality between strong and weak coupling. The NFL behavior is understood physically in terms of competing Kondo effects. The resulting frustration is relieved by inter-Majorana coupling which generates a second crossover to a regular Fermi liquid.Comment: 17 pages, 8 figure

The effects of Energised Greens™ upon blood acid-base balance during resting conditions

<p>Abstract</p> <p>Background</p> <p>The consumption of fresh fruit & vegetable in concentrate form (FVC) have recently become an alternative approach to combating excessive renal acid loads often associated with <it>Western Diets</it>. Additionally, these FVC's have been purported to induce metabolic alkalosis, which perhaps may enhance the blood buffering capacity of an individual. Therefore, the aim of this preliminary study was to profile the acid-base response after ingestion of an acute dose of fruit and vegetable extract (Energised Greens™ (EG), Nottingham, UK) and compare it to a standard, low dose (0.1 g·kg^-1) of sodium bicarbonate (NaHCO₃).</p> <p>Findings</p> <p>As part of a randomized, cross over design participants consumed 750 mL of water with either 9 g of EG (manufacturer recommendations), 0.1 g·kg^-1of NaHCO₃or a placebo (plain flour) in opaque encapsulated pills following an overnight fast. Capillary samples were obtained and analyzed every 15 min for a period of 120 min following ingestion. Significant interactions (p < 0.01), main effects for condition (p < 0.001) and time (p < 0.001) were evident for all acid-base variables (pH, HCO_3^-, BE). Interactions indicated significant elevation in blood alkalosis for only the NaHCO₃condition when compared to both placebo and EG from 15 to 120 minutes.</p> <p>Conclusions</p> <p>Despite previous findings of elevated blood pH following acute mineral supplementation, manufacturer recommended doses of EG do not induce any significant changes in acid-base regulation in resting males.</p